The mechanism of cartilage destruction in rheumatoid arthritis

Cartilage destruction in rheumatoid arthritis.

Synovial fibroblasts represent an important source of matrix degrading enzymes mediating joint destruction in rheumatoid arthritis. In our search for new pathways for the activation of synovial fibroblasts we have detected endogenous retroviral sequences, like the line 1 element (L1). To study the functional role of L1 we transduced synovial fibroblasts with L1 constructs and showed that L1 ind...

Pathogenesis of bone and cartilage destruction in rheumatoid arthritis.

Proinflammatory cytokines, such as interleukin-1 (IL-1) and tumour necrosis factor alpha (TNFalpha), have been implicated in the dysregulation of bone and cartilage remodelling characteristic of rheumatoid arthritis (RA). With respect to bone remodelling, both of these cytokines have been shown to up-regulate the production of the receptor activator of nuclear factor-kappaB ligand, which acts t...

Molecular mechanism of bone destruction in rheumatoid arthritis

Experimental Study on Protective Role of NSAID on Articular Cartilage Destruction in Septic Arthritis

Background: Surgical drainage and antibiotic therapy are the cornerstones of treatment protocols in septic arthritis; however, in some circumstances, the diagnosis and initiation of treatment may be retarded by slow disease progression or the time when the patient’s condition precludes early surgery. Therefore, it is beneficial to find ways to reduce the amount of articular injury. This study a...

Mechanism of cartilage destruction in osteoarthritis.

Osteoarthritis (OA) is one of the most common diseases among the elderly. For many years, OA was considered a normal result of the aging process with few treatment options. Remarkable progress in understanding OA cartilage has been achieved in recent years. The application of technical advances to clinical studies of chondrocytes and cartilage tissue metabolism will provide important new insigh...